Immunochemotherapy

Editorial

Accumulating evidence indicates that the innate and adaptive immune systems make a crucial contribution to the antitumour effects of conventional chemotherapy- and radiotherapy-based cancer treatments. Moreover, the molecular and cellular bases of the immunogenicity of cell death induced by cytotoxic agents are being progressively unravelled, challenging the guidelines that currently govern the development of anticancer drugs. The general topic of this conference will be the immunological aspects of conventional cancer treatments and the establishment of a new paradigm in cancer research: to obtain complete and permanent cure by chemotherapy, the immune system must mount an immune response against residual cancer (stem) cells. Based on these promising advances, we anticipate that future success in the fight against cancer will rely on the development and clinical application of combined chemo- and immunotherapy

To some extent, this conference is the final culmination of two prior conferences that have been organized in 2006: "The immune response against dying tumor cells" and in 2007: "Death, Danger and Immunity. These past two conferences have given rise to several special issues that are published in high impact factor journals, namely Immunological Reviews (2007), Cell Death & Differentiation(2007) as well as Current Opinion in Immunology (to be published in 2008), simply to mention the fact that the scientific community is interested in this topic.

At difference with other conferences, the «First International Conference on Immunochemotherapy» will deal with translational aspects of the concept that chemotherapy may and should induce an anti-cancer immune response. As a result, the conference will deal both with experimental and clinical aspects of immunochemotherapy, including the design and analysis of clinical trials, some of which are extremely promising.

We would like to thank the speakers who kindly accepted to share new insights on this fascinating topic both on experimental and clinical levels.

We are very much looking forward to welcome you in Paris to this exciting event .

Scientific commitee

Curie

Scientific commitee

Guido Kroemer
INSERM Unit U848, "Apoptosis, Cancer & Immunity"
Institut Gustave Roussy, Villejuif, France

Laurence Zitvogel
INSERM Unit U805
Institut Gustave Roussy, Villejuif, France

Sebastian Amigorena
INSERM U 653 "Immunity and Cancer"
Institut Curie, Paris, France

Stephane de Botton
Departement de Medecine – Sce d’Hematologie
Institut Gustave Roussy, Villejuif, France

Malcom Adams
Cancer Services Velindre NHS Trust Cardiff , UK

Organization commitee

Antoine Tesnière
INSERM U848 “Cancer, Apoptosis and Immunity”
Institut Gustave Roussy, Villejuif, France

Curie

Preliminary Program

<<Friday October 17th, 2008 >> - << Saturday October 18th, 2008>>

Friday October 17th, 2008
8.00 am	Registration of participants
8.30 am	Grand opening Pr Claude Huriet, Président de l'Institut Curie, Paris Introduction Guido Kroemer (Institut Gustave Roussy, Villejuif, France)
9.00 – 10.30 am	Session 1: Immunogenic anti-cancer chemotherapy as an emerging concept Chairperson: Laurence Zitvogel 9.00 : Mark J. Smyth (Peter MacCallum Cancer Centre, Melbourne, Australia): Anti-cancer immunosurveillance and anti-cancer immune responses 9.30: Robert Schreiber (Washington University School of Medicine, St. Louis, MO, USA): Immunoediting and cancer dormancy 10.00 : Wolf-Hervé Fridman (Hôpital Européen Georges Pompidou, Paris, France).
10.30 – 11.00 am	Coffee- break - Poster session
11.00 am – 1.00 pm	Session 2: Death and danger signals Chairperson: Sebastian Amigorena 11.00: Guido Kroemer (INSERM, Institut Gustave Roussy, Univ Paris-Sud, Villejuif, France): Immunogenic cancer cell death: the goal of immunochemotherapy 11.30: Madhav V. Dhodapkar (Rockefeller University, New York, USA): Heat shock proteins at the surface of dying tumor cells 12.00: Jesus Gil (Hammersmith Hospital Campus, London, UK) Secreting senescence: an unexpected role for CXCR2 chemokines 12.30 Peter Vandenabeele (University of Ghent, Belgium) Apoptosis, necrosis and autophagy elicit distinct mechanisms of corpse removal
1.00 pm – 2.00 pm	Lunch- Poster session
2.00 pm – 300 pm	Session 2: Death and danger signals (continuation) Chairperson: Guido Kroemer 2.00: Sebastian Amigorena (INSERM, Institut Curie, Paris, France) Antigen presentation by dendritic cells: an update 2.30: Matthew L. Albert (Pasteur Institute, Paris, France) Molecular determinants of immunogenic cell death
3.00 pm – 4.00 pm	Session 3: The perception of danger signals Chairperson: Jules Hoffman 3.00: Gabriel Nunes (University of Michigan, Ann Arbor, MI, USA): Pyroptosis and the inflammasome: a new type of response to danger 3.30: Georges Prendergast (Lankenau Institute for Medical Research, Wynnewood, USA) T cells and tumoral immune escape
4.00 pm – 4.30 pm	Coffee-break- Poster session
4.30 pm – 5.30 pm	Session 3: The perception of danger signals (continuation) Chairperson: Matthew Albert 4.30 Danger signaling via toll-like receptors Jules Hoffmann (IGBMC, Strasbourg, France) 5.00 How dendritic cells sense immunogenic cell death Laurence Zitvogel (Institut Gustave Roussy, INSERM, Univ. Paris-Sud, Villejuif, France)
5.30 pm – 6.10 pm	Leopoldina lecture Cytoplasmic receptors for the perception of dangerTadatsugu Taniguchi (University of Tokyo, Japan)
6.30 pm	Friday adjournment
7.30 pm – 11.30 pm	Gala dinner - Cruise on the Seine river

Saturday October 18th, 2008
8.00 am	Registration of participants
8.30 – 10.30 am	Session 4: Dendritic cells: decoding the trigger 8.30: Drew M. Pardoll (Johns Hopkins University School of Medicine, Baltimore, USA) Title to be determined 9.00: Jacques Banchereau (Baylor Institute, Dallas, TX, USA) Anti-cancer vaccination strategies based on the use of dendritic cells 9.30: Miriam Merad (Memorial Sloan Kettering Institute, New York, USA) Tolerogenic versus immunogenic signals emanating from dendritic cells 10.00: Frederic Geissmann (INSERM, Necker Hospital, Paris, France) Dendritic cells and their precursors
10.30 – 11.00 am	Coffee-break - Poster session
11.00 am – 12.15 am	Session 5: Poster session Chairperson: Miriam Merad 11.00: Tumor therapy via antigen targeting to a novel C-type lectin restricted to dendritic cells David Sancho (Cancer Research UK, London, UK) 11.15: Dendritic cell and subsequent effector T cell polarization by dying tumor cells Divya Sekar (Frankfurt, Germany) 11.30: Dendritic cell vaccination combined with oxaliplatin/capecitabinechemotherapy in colorectal cancer Joost Lesterhuis (Radboud University Nijmegen Medical Centre, The Netherlands) 11.45: Triggering of TLR7 and TLR8 expressed by human lung cancerinduces cell survival and chemoresistance Julien Cherfils Vicini (Cordeliers research center, Paris, France) 12.00Diversification of TCR repertoire in melanoma patients treatedwith chemotherapy before vaccination Paola Nistico (Regina Elena Cancer Institute, Rome, Italy)
12.15 – 1.30 am	Lunch - Poster session
1.30 – 4.00 pm	Session 6 : Clinical studies and beyond Chairperson: Malcom Adams 1.30 Learning from immunotherapy clinical studies Malcom Adams (Cancer Services, Velindre NHS Trust, Cardiff, UK) 2.00: Gerold Schuler (University of Erlangen, Germany): A meta-analysis of dendritic cell vaccination trials 2.30: Anna Karolina Palucka (Baylor Institute, Dallas, TX, USA): Dentritic cell vaccination trials at Baylor Institute 3.00: Jean-Edouard Gairin (Pierre Fabre Oncologie) 3.30: Bruno Quesnel (INSERM, Lille, France)
4.00 –4.30 pm	Coffee-break - Poster session
4.30 pm – 6.30 pm	Session 6 : Clinical studies and beyond (continuation) Chairperson: Stéphane de Botton 4.30: Ron Levy (Division of Oncology Stanford, CA, USA) 5.00: Jean-Yves Bonnefoy (Transgene) 5.30: Yannis Morel (Innate Pharma) 6.00: Ira Mellman (Genentech, San Francisco, CA, USA)
6.30 – 6.45 pm	Concluding remarks - discussion
End of the Conference

Speakers

Anna Karolina Palucka	Baylor Institute	Dallas, TX, USA
Bruno Quesnel	Hématologue, CHRU	Lille, France
Frederic Geissmann	INSERM, Necker Hospital	Paris, France
Gabriel Nunez	University of Michigan	Ann Arbor, MI, USA
Gerold Schuler	University of Erlangen	Germany
Guido Kroemer	INSERM, Institut Gustave Roussy, Univ Paris-Sud	Villejuif, France
Ira Mellman	Genentech	San Francisco , USA
Jacques Banchereau	Baylor Institute	Dallas, TX, USA
James Allison	Memorial Sloan Kettering Institute	New York , USA
Jean Edouard Gairin	Pierre Fabre Oncologie	Boulogne, France
John Savill	University of Edinburgh	Scotland, UK
Jules Hoffmann	IGBMC	Strasbourg, France
Laurence Zitvogel	Institut Gustave Roussy, INSERM, Univ Paris-Sud	Villejuif, France
Madhav V. Dhodapkar	Rockefeller University	New York, USA
Malcom Adams	Cancer Services, Velindre NHS Trust	Cardiff, UK
Mark J. Smyth	Peter MacCallum Cancer Centre	Melbourne, Australia
Matthew L. Albert	Pasteur Institute	Paris, France
Miriam Merad	Memorial Sloan Kettering Institute	New York, USA
Peter Vandenabeele	University of Ghent	Belgium
Richard Piani	Hemispherx	Philadelphia , USA
Robert Schreiber	Washington University School of Medicine	St. Louis, MO, USA
Ruslan Medzhitov	Yale University	USA
Scott W. Lowe	Cold Spring Harbor Laboratory	New York, USA
Sebastian Amigorena	INSERM, Institut Curie	Paris, France
Tadatsugu Taniguchi	University of Tokyo	Japan
Xuetao Cao	Second Military Medical University	Shanghai, China
Yannis Morel	Innate Pharma	Marseille, France

Registration Fees

	Until 27th June 2008	From 28th June 2008
Industrials	400,00 €	500,00 €
Academics	250,00 €	350,00 €
Students*	150,00 €	250,00 €
Gala dinner	50,00 €	60,00 €

* To benefit from student fee, please send a photocopy of your present student card signed by your research director.

Registration fee covers cost for admission to the scientific sessions, abstracts book, coffee breaks and lunches.

A refund of the registration fee, less an administration charge of 50 €, will be made if a written notification of cancellation is received no later than September 19th, 2008. No refunds will be made after that date. A substitute participant will be welcomed at no extra charge. Please note that all refunds will be issued after the conference

Venue :

The Institut Curie continues, according to the will of Marie Curie, a mission of treatment and research against cancer. The continuity of research to the care constitutes the originality of the Curie model to support the excellence, the innovation and the quality of patient management.
Foundation accredited as a public service body since, the Institut Curie profits from the generosity of the public by donation, legacy and sponsorship.

Institut Curie – Salle Constant-Burg
12 rue Lhomond
75248 PARIS cedex 05
www.curie.fr

location

The Institut Curie is delimited by Pierre and Marie Curie street, Ulm street and Louis Thuillier street.
The Constant-Burg conference room is located in the Lhomond street
The nearest RER station is « Luxembourg », on line B.
Take Gay Lussac street, then the first left (Royer Collard street) to Saint-Jacques street ; go up right and then turn to the first left, Pierre and Marie Curie street.

The metro stations indicated on the map (by lozenge) are :

Port Royal (RER B)
Luxembourg (RER B)
Saint Michel (RER B et C, Metros 4 et 10)
Maubert Mutualité (Metro 10)
Cardinal Lemoine (Metro 10)
Place Monge (Metro 7)
Censier Daubenton (Metro 7)

The bus station indicated (by round) are :

Feuillantines (Bus 21 et 27)
Gay-Lussac (Bus 21 et 27)
Luxembourg (Bus 21, 27, 38, 82, 85)
Panthéon (Bus 84 et 89) these buses are not working on sunday
Collège de France (Bus 63, 86, 87)
Saint Jacques (Bus 24, 47, 63, 86, 87)
Pont de l'archevéché (Bus 24)
Place Monge (Bus 47)
Censier Daubenton (Bus 47)
Port Royal - Bertholet (Bus 83, 91)
Port Royal - Saint-Jacques (Bus 83, 91)

Greetings

We would like to confirm your registration for the 1stInternational Conference on Immunochemotherapy at the Institut Curie in Paris. Registration desk will open October 17th, at 8:00 am. The conference will start at 8.30 am, in the Constant Burg Conference center, located at the ground floor of the Institut Curie Research center, 12 Rue Lhomond 75005PARIS

Please find below practical informations and details for this exciting meeting.

Maps

Institut Curie is located in the very center of Paris, nearby the Pantheon, and at walking distance from le Jardin du Luxembourg. You can easily access the conference center by Bus (Line21and 27, station Feuillantine), by Metro (Station Censier Daubenton), or by RER (line B, Station Luxembourg).

Abstracts and Posters

If you have submitted an abstract, its acceptance has been recently notified to you by the scientific committee. Practical information on poster preparation and presentation are detailed in the acceptance email.

Gala Dinner

The organizers of the1stInternationalConference on Immunochemotherapy are thrilled that you will be visiting Paris in just a few short weeks! Join us on Friday evening, October 17th, for an exciting evening of cruising on the Seine river. Les Yachts de Paris’ famous boat, L’excellence, will welcome you for an extraordinary cruise in the heart of Paris. A shuttle bus will depart the conference center at 7:00 p.m. Guests will enjoy a drink outside if the weather allows it, and a fine diner will be served during our night trip inside Paris historical center. For more information on the boat trip and dinner, please visit http://www.yachtsdeparis.fr/en/.

Please register on our website: www.immunochemotherapy.com

We are very much looking forward to meeting you in Paris for this exciting conference!

For the organization commitee

Contact : COMM Santé –Audrey Morisset

Mail :audrey.morisset@comm-sante.com

Phone : +33 (0)557 97 19 19 / Fax : + 33 (0)5 57 97 19 15

Airport :

Airport Roissy - Charles de Gaulle (CDG)
Information service : +33 1 48 62 22 80 ou +33 1 42 62 12 12
http://www.aeroportsdeparis.fr/Adp/en-GB/Passagers/
23 km north of Paris, motorway A1

Airport Orly

Information service : +33 1 49 75 15 15 or +33 1 49 75 52 52 (Orly South)
http://www.aeroportsdeparis.fr/Adp/en-GB/Passagers/
14 km south of Paris, motorway A6

Air France Approved Number :

Air France

Identifier Code 03988AF / Valid for travel from 12/10/2008 to 23/10/2008.
Discounts are applied to a wide range of airfares, in all classes of travel, Espace Première (First), Espace Affaires (Business) and Tempo (Coach) on all Air France flights worldwide. To access the preferential fares granted for this event, use this link: http://www.airfrance-globalmeetings.com or the website of this event.
This present document of the event serves to justify the application of the preferential airfare. Keep it with you as you may be asked for it at any point of your journey. To locate your nearest Air France sales point, consult: www.airfrance.com

Public transport:

See practical information on the website of the Institut Curie and the website of the tube (RATP).

Accommodation

Exclusive reservations with special discounts have been booked for the congress participants in the following hotels, nearby Institut Curie.

To make a reservation, please contact our partner ABOTEL.

Contact: elise@abotelparis.com - Tel. +33 (0)1 47 27 15 15 - Fax : +33(0)1 47 27 05 87

Please download the hotels localization and complete the hotel booking form